After years of struggling with infertility, Prison Break actress Camille Guaty is expecting a baby boy this fall with husband Sy Rhys Kaye.

“The day the nurse called to tell me I was pregnant, I burst out crying!” the 43-year-old TV star tells PEOPLE exclusively. “I made her say it to me four or five times. I feel so grateful now and can’t wait to meet our son.”

Guaty’s emotional journey to motherhood began nearly six years ago when she and her songwriter-producer husband began trying for a baby naturally when she was 37.

A year later, Guaty and Kaye, 39, visited their first in-vitro fertilization clinic, where the actress was told her ovarian reserve was “equivalent to that of a 50-year-old.”

“You never think this is going to be your story,” she says. “Women come up to me and say, ‘If you’re 43 and pregnant, I have plenty of time!’ I just want to say, ‘It didn’t happen the way you think it did.’”

The couple went through five failed rounds of IVF and also tried intrauterine insemination — which involves placing the sperm directly into the uterus — but were still unable to get pregnant.

Two years ago, Guaty visited another doctor in New York who felt confident about her chances of conceiving and put her on a three-month regimen to start her sixth round of IVF.

“I thought he was the end-all, be-all,” says Guaty. “But then I took such a nosedive in my fertility in those three months that he was like, ‘I don’t know what happened!’ My fertility was pretty much nonexistent.”

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